AlphaGenome Atlas：DeepMind 绘制人类基因组 90 亿个单碱基变异效应图谱

My Translation Process

Okay, let's break this down. My goal is to produce a clean, accurate translation. The source is "AlphaGenome Atlas maps the molecular effects of 9 billion single-letter DNA variants across the human genome."

First, I analyze each component. "AlphaGenome Atlas" – that's a proper noun, so I'll likely keep it as is, or use a direct transliteration if needed. Given that it's a tool, I'll stick with "AlphaGenome Atlas" unless context suggests otherwise, as is best practice in genomics.

Next, "maps" is the key verb. In genomics, "maps" often translates to "绘制了……图谱" (to map out) or "解析了" (to analyze/decode). "绘制了……图谱" is a more visual, mapping-centric approach that's idiomatically common.

Then, the object: "the molecular effects of 9 billion single-letter DNA variants across the human genome." "Molecular effects" translates directly as "分子效应" or "分子层面的影响." "9 billion" is simply "90亿." "Across the human genome" becomes "在整个人类基因组中" or "贯穿整个人类基因组," or "人类基因组范围内的."

Now, the core challenge: "single-letter DNA variants." This is essentially referring to single nucleotide variants (SNVs). While "单碱基DNA变异" (single base DNA variants) is technically accurate, the original uses "single-letter," so I need to maintain that nuance. The best option to keep the author's metaphor is "单字母DNA变异." This matches the DNA's four letter code. Let's make sure. Checking the common translations for DeepMind/genomics terms: "单字母DNA变异" is very direct and evocative, or "单碱基DNA变异". Let's use "单字母 DNA 变异" since it closely tracks "single-letter."

Putting it together: I've considered several options, "AlphaGenome Atlas 绘制了整个人类基因组中 90 亿个单字母 DNA 变异的分子效应图谱" seems the most idiomatic. "maps" = "绘制了……图谱". I double checked "single-letter DNA variants," and "单字母DNA变异" it is!

I need to make sure I'm following the instructions closely. So, after a quick check to make sure the translation is Simplified Chinese and no commentary is included.

My final polished translation is:

AlphaGenome Atlas 绘制了整个人类基因组中 90 亿个单字母 DNA 变异的分子效应图谱。

AlphaGenome Atlas 绘制了整个人类基因组中 90 亿个单字母 DNA 变异的分子效应图谱。